Abstract: The Accrual to Clinical Trials (ACT) Network – a HIPAA-compliant tool for querying de-identified electronic health record data – includes 21 CTSA academic medical research centers (contributing 60+ million patient records), with 27 additional CTSAs onboarding. ACT dissemination-implementation is grounded in systems-thinking and Diffusion of Innovation Theory: (1) emphasizing relative advantages of using big data for cohort discovery/trial design and compatibility with existing ‘Jobs to be Done’ workflows; (2) involving both mass media (co-branded web resources) and interpersonal (local CTSA) communication channels; (3) acknowledging adoption as a time-based process and (4) leveraging CTSA social norms/incentives for translating clinical innovation. Core dissemination resources were provided nationally to jumpstart local CTSA adaptation and use. Time-to-adoption metrics for 19 CTSAs are presented. Dissemination-implementation planning followed technical implementation. Median time from e-mail dissemination invitation to “quick start” web-conference calls was 37 days (IQR=30–49), reflecting an internal process of identifying key CTSA stakeholders beyond the teams who established technical readiness. Median time was 46 days (IQR =17–53) to respond to a request for launch details to create a locally-adapted ACT website resource powered by the national platform (www.ACTNetwork.us/national). This timeframe reflects significant multi-disciplinary workflow integration not addressed during uni-disciplinary IT implementation. Overall, the median time from e-mail invitation to delivery of locally-customized ACT dissemination resources was 121 days (IQR=121–147) for the 11 CTSAs who have completed this step, reflecting both local and national dissemination activities and the natural academic calendar rhythm. National scale-up and system-based integration of new big data technology across health research organizations illustrates the phenomenon of “adoption as a time-based process”. Studying the steps involved for the ACT Network can inform future scale-up of innovation through the CTSA consortium. Performing technical readiness and dissemination planning activities in parallel (versus sequentially) is one means for accelerating implementation.